• “Glutathione is the body’s main powerhouse for defusing and disposing of free radicals…”¹
• U.S. Patent RE39734 description: “Nutritional or Therapeutic Compositions to increase Bodily Glutathione levels”.
• ProImmune^® is not Glutathione, which is a small tripeptide molecule, but the vital precursors for the intracellular synthesis of Glutathione, widely recognized as The Master Antioxidant.
• ProImmune^® comprises amino acids (I-cystine, glutamine, glycine) and a cofactor, a special selenium compound (selenomethionine or selenocystine).
• ProImmune^® is physiological. ProImmune is not a synthetic. The components are natural to the body, and combined in a patented equation to facilitate Glutathione syntheses intracellularly.
• ProImmune^® ’s Immune Formulation 200^® is listed in the 2009 Physicians’ Desk Reference (PDR), page 2585, with image of the package on page 321.
• ProImmune^® is a mildly sweet white powder with no aftertaste that can be sprinkled on foods or added to beverages. ProImmune^® contains no carbohydrates, filler, additives, or preservatives.
• “If you deplete Glutathione, the cell disintegrates and loses its immune activity.”²
• ProImmune^® is supported with scientific university research demonstrating it to be effective, physiologically and economically, in increasing intracellular synthesis of Glutathione and raising levels of this Master Antioxidant: “Proof of Principle.”
• The Research Centers in Minority Institutions (RCMI), a consortium of 18 medical research institutions, has committed $17.5M annually, funded by the National Institutes of Health (NIH), after their initial study of ProImmune^®, to research and conduct clinical studies regarding ProImmune^®’s influence on various aspects of healthy, including aging. The contract is for five (5) years and a total of $87,500,000.00.
• Recent research results from Charles R. Drew University of Medicine and Science and David Geffen School of Medicine at UCLA showed the effects of Spermine introduction to HASM cells, comparing results of three different treatments of the cells. Performance of oxidative stress-reducers in ProImmune^® versus glutathione and NAC showed ProImmune^® surpassed the compound NAC in protecting human aortic smooth muscle cells from Spermine induced apoptosis. And cells treated with ProImmune^® carried out their normal functions with minimal interference.
• Extensive university research to understand what the introduction of RE39734 in the cell represents is underway.
• Glutathione has a turnover rate in the body every 36 hours; the body’s cellular reservoirs of usable Glutathione need to be replenished, under ordinary conditions, with the components that ProImmune^® provides (see above), the same components partially provided by our diet, for the synthesis of Glutathione intracellularly, as nature has designed.
• Would you expect to consume components of ProImmune^® in certain foods that you ordinarily eat? Yes, but to maintain Glutathione levels will depend on the quality and quantity of those certain foods.
• The two cytosolic enzymes which are essential for the amino acids to re-assimilate and form Glutathione are only present in the cytoplasm of the cell (intracellularly).
• How to get Cysteine safely, efficiently and economically into the cell was the challenge and the scientific impasse. The answer was to use Cystine (which is actually two Cysteines yoked in a disulfide bond) as a safe transport of Cysteine into the cell.
• You will notice that ProImmune^® does not completely hydrolyze (dissolve in water), although it is conveniently carried in colloidal liquids (e.g., V-8 Juice, milk, etc.). In water, the indissolvable part is the amino acid Cystine, which only releases its two Cysteines when it enters the cell. Nevertheless, as soon as Cystine meets your mucosal membranes (beginning in the mouth) it begins to be absorbed into the cell, where it releases the two Cysteines. Then your cells can begin synthesizing Glutathione.
• Dr. Albert B. Crum’s invention foresaw Cystine as being the primary systemic carrier of Cysteine, hence this coupling’s being the reason why Cystine could function as the primary carrier of Cysteine…the Cysteine unprotected molecule (with its thiol group) was too active, too labile, too oxidizable, too toxic to be converted into Glutathione or directly obtain intracellular status. However, once it was able to attain the intracellular milieu, this Cysteine would be met with the two cytosolic enzymes which could bind all components into the first and second stages of Glutathione synthesis.
• Dosing: the brilliance of nature has designed intracellular Glutathione synthesis with shut down mechanisms through enzymatic action. Once the cell’s reservoir is filled with the optimal level of the necessary components to maintain Glutathione replenishment, the unutilized components are reassigned within the cell to protein formation or other nourishment; the body is thus protected from overdoes with the components supplied to manufacture Glutathione, delivered by the components of ProImmune^®, or the daily diet.
• Historically, attempts to assist Glutathione replenishment (since 1888) have included:
• Oral Glutathione, which the Autism Research Institute has acknowledged that only 10 to 15% of the administration can survive the gastrointestinal tract’s enzymes (trypsin and pepsin).
• Intravenous, effective but short-lived, given the turnover rate of Glutathione; it’s also expensive (reported as $1000-$3000 per does), labor intensive, and an aggressive treatment.
• Both large molecule administration utilizing constituent vital amino acids in colostrums and undenatured whey, and nasal/mucosae administration provide short term and local advantage.
• N-acetylcysteine (NAC) has for years been the most-often used method to increase bodily Glutathione levels; NAC is a synthetic, not natural to the body; the recent university research referenced has shown ProImmune^® to be more effective than NAC.

Glutathione synthesis adjusts to an optimal level on an “as needed” basis. The Glutathione molecule itself cannot be imported into the cell. Glutathione synthesis occurs intracellularly and as per the body’s availability of the required enzymes for that synthesis. This is how Glutathione synthesis is designed to function on behalf of the immune system.

¹Jean Carper, Stop Aging Now, Harper-Collins Publishing © 1996, p124
²Jean Carper, Stop Aging Now, Harper-Collins Publishing © 1996, p125